Published ahead of print on May 1, 2008
doi: 10.3174/ajnr.A1091
Cerebral Blood Flow by Using Pulsed Arterial Spin-Labeling in Elderly Subjects with White Matter Hyperintensities
A.J. Bastos-Leitea,b,c,
J.P.A. Kuijerd,
S.A.R.B. Romboutsd,e,
E. Sanz-Arigitad,
E.C. van Straatenb,f,
A.A. Gouwb,f,
W.M. van der Flierb,f,
P. Scheltensb,f and
F. Barkhofa,b,g
a Image Analysis Center, VU University Medical Center, Amsterdam, the Netherlands
b Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
c Department of Medical Imaging, Faculty of Medicine, University of Oporto, Oporto, Portugal
d Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, the Netherlands
e Department of Radiology, Leiden Institute for Brain and Cognition, Leiden University Institute for Psychological Research, Leiden University Medical Center; Leiden, the Netherlands
f Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands
g Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands
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Fig 2. A, Axial FLAIR images, T1-weighted images, cortical gray matter CBF images, subcortical CBF images, and global CBF images combining all gray and white matter at the level of the basal ganglia and thalamus (above) and at the level of cerebral white matter (below) from subject 4. B, Corresponding images from subject 18. On the CBF images, note that the cerebral cortex, the cortical-subcortical transition, and the thalamus are highly perfused structures. Also note the perfusion differences between subject 18 (with diffuse confluent WMH on FLAIR images) and subject 4 (with punctiform WMH on FLAIR images). Finally, on the subcortical and global CBF images from subject 18, note the relative hypoperfusion of the right thalamus, where a lacunar infarct occurs (arrow).
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