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AJNR - American Journal of Neuroradiology

Published ahead of print on May 15, 2008
doi: 10.3174/ajnr.A1111

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Whole-Tumor Perfusion CT Parameters and Glucose Metabolism Measurements in Head and Neck Squamous Cell Carcinomas: A Pilot Study Using Combined Positron-Emission Tomography/CT Imaging

S. Bisdas^a,b, K. Spicer^a and Z. Rumboldt^a

^a Department of Radiology, Medical University of South Carolina, Charleston, SC
^b Department of Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany

View larger version (48K): [in this window] [in a new window]   Fig 1. Tissue perfusion CT map (A) and PET/CT SUVmean map (B) of a 54-year-old woman with a SCCA in the skin on the left temporal side. Blood flow (A) map shows a hypervascularized area in the subcutaneous region with infiltration of the cutis (arrows). The increased perfusion of the neoplastic tissue is coupled with increased SUV uptake (B) in the FDG PET/CT imaging (arrows).

View larger version (45K): [in this window] [in a new window]   Fig 2. Regression analysis of the mean BF values in the tumor (triangles) and healthy tissue (circles) with the SUVmean. There is a positive significant correlation (r = 0.63; P = .011) in the tumor ROIs. Linear regression analysis showed SUVmean = 0.05 x BF + 2.22 (R2 = 0.45; P = .011) (regression line). The curved dashed lines show the 95% confidence intervals for the tumor ROIs means. The dashed line depicts the line of perfect agreement (equation line).

View larger version (26K): [in this window] [in a new window]   Fig 3. Regression analysis of the mean BF values in the tumor with the SUVmean ratios of tumor-to-nontumor tissue. There is a positive significant correlation (r = 0.64; P = .01) in the tumor ROIs. Linear regression analysis showed Ratio SUVmean = 0.14 x BF–3.48 (R2 = 0.42; P = .01) (regression line). The curved dashed lines show the 95% confidence intervals for means. The dashed line depicts the line of perfect agreement (equation line).