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AJNR - American Journal of Neuroradiology

Published ahead of print on June 12, 2008
doi: 10.3174/ajnr.A1169

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White Matter Changes Contribute to Corpus Callosum Atrophy in the Elderly: The LADIS Study

C. Ryberg^a,b, E. Rostrup^b, K. Sjöstrand^c, O.B. Paulson^b,d, F. Barkhof^e, P. Scheltens^f, E.C.W. van Straaten^f, F. Fazekas^g, R. Schmidt^g, T. Erkinjuntti^h, L.-O. Wahlundⁱ, A.M. Basile^j, L. Pantoni^j, D. Inzitari^j, G. Waldemar^a on behalf of the LADIS study group

^a Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
^b Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
^c Informatics and Mathematical Modelling, Technical University of Denmark, Copenhagen, Denmark
^d Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
^e Department of Radiology and Image Analysis Center, VU Medical Center, Amsterdam, the Netherlands
^f Department of Neurology, VU Medical Center, Amsterdam, the Netherlands
^g Department of Neurology, Medical University, Graz, Austria
^h Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
ⁱ Department of Clinical Neuroscience, NEUROTEC, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
^j Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy

View larger version (53K): [in this window] [in a new window]   Fig 1. The left panel shows axial views illustrating the delineation of 6 anatomic regions: frontal (green), parietal (turquoise), temporal (yellow), basal ganglia (red), occipital lobes (pink), infratentorial regions (purple); see details in text. The right panel shows the average distribution of ARWMC projected onto orthogonal sections of the group-averaged T2-weighted image. The color-coding indicates the frequency of ARWMC occurrence, ranging from 5% (dark blue) to 30% and above (dark red).

View larger version (22K): [in this window] [in a new window]   Fig 2. Segmentation and subdivision of the CC area into 5 distinct subregions obtained from the normalized midsagittal T1 (MPRAGE) scans. A radial partitioning scheme is used for regional analyses of the CC. CC1 indicates rostrum and genu; CC2, rostral body; CC3, midbody; CC4, isthmus; CC5, splenium.

View larger version (39K): [in this window] [in a new window]   Fig 3. The correlation between the area of each of the 10 CC subregions and the volume of ARWMC in each of 5 hemispheric regions and the whole brain. To obtain a better illustration of the regional specificity between CC atrophy and ARWMC, we subdivided the CC into 10 subregions and not 5 subregions as reported in Fig 2. The color code from blue to red indicates the magnitude of regression coefficients.

View larger version (20K): [in this window] [in a new window]   Fig 4. Comparison of mean total callosal area measured on normalized MR imaging in nondisabled elderly subjects, classified by severity of ARWMC (Fazekas ratings 1, 2, and 3). Vertical bars indicate SDs. The white figures indicate the mean ARWMC volumes. Triple asterisks indicate P < .001 (ANOVA test).