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AJNR - American Journal of Neuroradiology

Published ahead of print on July 3, 2008
doi: 10.3174/ajnr.A1122

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Isolated Cortical Signal Increase on MR Imaging as a Frequent Lesion Pattern in Sporadic Creutzfeldt-Jakob Disease

B. Meissner^a,e, K. Kallenberg^b, P. Sanchez-Juan^c,d, A. Krasnianski^a, U. Heinemann^a, D. Varges^a, M. Knauth^b and I. Zerr^a

^a National TSE Reference Center at the Department of Neurology, Georg-August University of Göttingen, Göttingen, Germany
^b Department of Neuroradiology and MR Research in Neurology and Psychiatry, Georg-August University of Göttingen, Göttingen, Germany
^c Foundation Marqués de Valdecilla, El Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain
^d Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of Zürich, Zürich, Switzerland
^e Department of Gerontopsychiatry, University of Zürich, Zürich, Switzerland

View larger version (16K): [in this window] [in a new window]   Fig 1. Detection of cortical hyperintensities by FLAIR and DWI in 55 patients with CJD. (The cingulate gyrus and hippocampus are not displayed because the findings were not significant.)

View larger version (62K): [in this window] [in a new window]   Fig 2. MR imaging lesion patterns in sporadic CJD depicted by DWI.

View larger version (70K): [in this window] [in a new window]   Fig 3. Involvement of the frontal and parietal lobes in patients with isolated cortical hyperintensities. A, Sagittal FLAIR-weighted scan of a 58-year-old patient 3.5 months after the disease onset and 1 week before death showing signal-intensity increases of the frontal and parietal lobes. B, Axial FLAIR-weighted scan of the same patient showing frontal and parietal signal-intensity increases. C, Diffusion-weighted scan of the same patient showing frontal and parietal signal-intensity increases.