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AJNR - American Journal of Neuroradiology

Published ahead of print on July 24, 2008
doi: 10.3174/ajnr.A1210

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Classification of Carotid Stenosis by Millimeter CT Angiography Measures: Effects of Prevalence and Gender

E.S. Bartlett^a, T.D. Walters^b, S.P. Symons^c, R.I. Aviv^c and A.J. Fox^c

^a University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada
^b University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
^c University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

View larger version (24K): [in this window] [in a new window]   Fig 1. Interobserver agreement scatterplots (n = 319). A, Stenosis measures (in millimeters); ICC, 0.90 (95% CI, 0.88–0.92). B, Distal ICA measures (in millimeters); ICC, 0.79 (95% CI, 0.75–0.83).

View larger version (22K): [in this window] [in a new window]   Fig 2. Gender-specific linear regression lines between mean millimeter stenosis and their corresponding percent stenosis values. A, Female regression line (n = 157; adjusted R2 = 0.93). B, Male regression line (n = 162; adjusted R2= 0.90).

View larger version (39K): [in this window] [in a new window]   Fig 3. Gender-specific estimated percentage stenosis values (presented as 95% predictive intervals) corresponding to specific millimeter stenosis measures, calculated from the respective gender-specific linear regression models. The shaded areas represent the millimeter stenosis ranges that correspond to the estimated percentage stenosis ranges that include the 70% and 50% stenosis cut-off values (severe and moderate stenosis, respectively).

View larger version (16K): [in this window] [in a new window]   Fig 4. Severe stenosis ROC curves. A, Female (n = 157), area under the curve = 0.98 (95% CI, 0.96–1.0). B, Male (n = 162), area under the curve = 0.98 (95% CI, 0.96–1.0).

View larger version (16K): [in this window] [in a new window]   Fig 5. Moderate stenosis ROC curves. A, Female (n = 157), area under the curve = 0.98 (95% CI, 0.97–1.0). B, Male (n = 162), area under the curve = 0.98 (95% CI, 0.96–1.0).