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AJNR - American Journal of Neuroradiology

Published ahead of print on July 3, 2008
doi: 10.3174/ajnr.A1185

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Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide

H.A. Rowley^a, G. Scialfa^b, P.-y. Gao^c, J.A. Maldjian^d, D. Hassell^e, M.J. Kuhn^f, F.J. Wippold, II^g, M. Gallucci^h, B.C. Bowenⁱ, I.M. Schmalfuss^j, J. Ruscalleda^k, S. Bastianello^l and C. Colosimo^m

^a Department of Radiology, University of Wisconsin, Madison, Wis
^b Servizio di Neuroradiologia, Ospedale Niguarda Ca’ Granda, Milano, Italy
^c Beijing Tian Tan Hospital: No. 6, Beijing, China
^d Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC
^e Sunbelt Research Group, LLC, Mobile, Ala
^f Department of Radiology, Southern Illinois University School of Medicine, Springfield, Ill
^g Mallinckrodt Institute of Radiology, Washington University, St. Louis, Mo
^h Servizio di Risonanza Magnetica, Ospedale Nuovo S. Salvatore, L’Aquila AQ, Italy
ⁱ Department. of Radiology, University of Miami School of Medicine, Miami, Fla
^j Neuroradiology Research, University of Florida, Gainesville, Fla
^k Department. of Neuroradiology, Hospital de la Santa Cruz y San Pablo, Barcelona, Spain
^l Fondazione Istituto Neurologico Casimiro Mondino, Pavia, Italy
^m Department of Bioimaging and Radiological Sciences, University Hospital "A. Gemelli", Rome, Italy

View larger version (45K): [in this window] [in a new window]   Fig 1. Reader preference for gadobenate dimeglumine or gadodiamide based on blinded qualitative evaluation. Each reader expresses a highly significant (P < .0001) preference for gadobenate dimeglumine for each parameter. Note that the number of patients for whom equality is expressed is not shown.

View larger version (136K): [in this window] [in a new window]   Fig 2. Glioblastoma with recurrent disease. This 55-year-old woman shows more conspicuous enhancement (arrows) in the right posterior temporal lobe with gadobenate dimeglumine than gadodiamide for both SE and GRE sequences. Although there are differences in angulation, changes were confirmed by review of all adjacent sections.

View larger version (90K): [in this window] [in a new window]   Fig 3. A 32-year-old woman with primary cerebellar glioma, which had previously been resected. A solid nodule of enhancement (arrow) is seen convincingly on the gadobenate dimeglumine–enhanced image. The clear visualization of contrast enhancement was important in postoperative decision making.

View larger version (104K): [in this window] [in a new window]   Fig 4. A 46-year-old man with a primary anaplastic carcinoma of the small bowel who developed sensory changes in the left upper extremity. The solitary metastasis (arrow) in the right superior frontal gyrus is only visualized on the gadobenate dimeglumine–enhanced image.