AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on July 24, 2008
doi: 10.3174/ajnr.A1190
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quattrone, A.
Right arrow Articles by Salsone, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quattrone, A.
Right arrow Articles by Salsone, M.

Essential Head Tremor Is Associated with Cerebellar Vermis Atrophy: A Volumetric and Voxel-Based Morphometry MR Imaging Study

A. Quattronea,b, A. Cerasaa, D. Messinaa,b, G. Nicolettia,b, G.E. Hagbergc, L. Lemieuxd, F. Novellinob, P. Lanzaa, G. Arabiaa and M. Salsoneb

a Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
b Institute of Neurology, University "Magna Graecia," Catanzaro, Italy
c IRCCS Fondazione Santa Lucia, Rome, Italy
d Department of Clinical and Experimental Epilepsy, University College London, Institute of Neurology, Queen Square, London, UK


Figure 1
View larger version (131K):
[in this window]
[in a new window]

  		Fig 1. Sample manual region-of-interest tracings assessing planimetric measurements of the vermal-functional areas by using the MRreg software.14 Data are shown for a control subject with no atrophy. A, The anterior lobule. B, The posterior superior lobule. C, The posterior inferior lobule. A + B + C = midsagittal vermal area.


Figure 2
View larger version (45K):
[in this window]
[in a new window]

  		Fig 2. Results from an optimized VBM analysis showing significant cerebellar atrophy at the level of the anterior lobe, above that occurring globally, selectively in patients with both a-ET and h-ET (Pcorrected < .001). Data analyses have been further corrected for age and sex. The maps are superimposed on the T1-weighted image averaged across all participants. The bar graphs give the mean and SD GM volume of voxels showing peak differences in the vermis. Patients with only a-ET display a tendency toward a CV loss.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X