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AJNR - American Journal of Neuroradiology

Published ahead of print on August 13, 2008
doi: 10.3174/ajnr.A1232

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Arterial Spin-Labeling MR Imaging Measurements of Timing Parameters in Patients with a Carotid Artery Occlusion

R.P.H. Bokkers^a, P.J. van Laar^b, K.C.C. van de Ven^c, L.J. Kapelle^d, C.J.M. Klijn^d and J. Hendrikse^a

^a Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands
^b Department of Radiology, Meander Medical Center, Amersfoort, the Netherlands
^c Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands
^d Department of Neurology, University Medical Center Utrecht, Utrecht, the Netherlands

View larger version (90K): [in this window] [in a new window]   Fig 1. A, sagittal orientation image illustrating the planning of the imaging section (1) and the arterial spin-labeling slab (2) parallel to the orbitomeatal angle. B, regions of interest used for quantification of the hemodynamic parameters. In each hemisphere, 2 regions of interests were drawn in the frontal lobe, and 1, in the frontal parietal, parietal occipital, and occipital regions.

View larger version (32K): [in this window] [in a new window]   Fig 2. Measured perfusion images of a 53-year-old man with a unilateral left-sided ICA occlusion. The images show the absolute cerebral blood flow (A), transit time (B), and trailing edge (C) maps. Decreased cerebral blood flow, increased transit time, and increased trailing edge can be appreciated in the left hemisphere.

View larger version (18K): [in this window] [in a new window]   Fig 3. Cerebral blood flow (mean ± SEM) in the regions of the hemisphere ipsi- and contralateral to the occlusion and of the control group. Asterisk indicates P < .05; double asterisks, P < .01, a significant difference between the hemisphere ipsilateral to the ICA occlusion and the control subjects; number sign, a significant (P < .05) difference between the hemisphere contralateral to the ICA occlusion and the control subjects.

View larger version (28K): [in this window] [in a new window]   Fig 4. Transit time and trailing edge time (mean ± SEM) in the regions of the hemisphere ipsi- and contralateral to the occlusion and of the control group. Asterisk indicates P < .05; double asterisks, P < .01, a significant difference between the hemisphere ipsilateral to the ICA occlusion and the control subjects; number sign, a significant (P < .05) asymmetry between the hemisphere contralateral to the ICA occlusion and the control subjects; dagger, a significant (P < .01) difference between the hemisphere ipsi- and contralateral to the ICA occlusion.