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AJNR - American Journal of Neuroradiology

Published ahead of print on August 13, 2008
doi: 10.3174/ajnr.A1201

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Combined 3T Diffusion Tensor Tractography and ¹H-MR Spectroscopy in Motor Neuron Disease

M. Nelles^a, W. Block^a, F. Träber^a, U. Wüllner^b, H.H. Schild^a and H. Urbach^a

^a Department of Radiology, University of Bonn Medical Center, Bonn, Germany
^b Department of Neurology, University of Bonn Medical Center, Bonn, Germany

View larger version (45K): [in this window] [in a new window]   Fig 1. A, Illustration of spectroscopic VOI in the central region in axial (left hemisphere) and coronal (right hemisphere) T2-weighted planscan images (left, upper and lower row). Sample spectra (TR/TE, 2000/140 ms; H2O-suppressed) of a healthy control (right, upper row) and patient IV/7 (Table 1) (right, lower row). B, 3D DTT (left) with intersection lines (yellow) shown at the level of FA/MD measurements (precentral gyrus, corona radiata, internal capsule, cerebral peduncles, pons, and pyramid). Fibers are projected onto axial FA (right/upper row, precentral gyrus) and MD maps (right/lower row, internal capsule) to allow a guided region-of-interest placement along the corticospinal tract. FA and MD statistics were additionally averaged on the CSTs as a whole to account for a region-independent analysis.

View larger version (24K): [in this window] [in a new window]   Fig 2. A, NAA/Cho and NAA/PCr metabolite ratios for patient subgroups and controls. Both parameters are lowest in group IV (EE probable/definite [prob./def.]). B, FA boxplots of the central region for groups I–IV. Mean FA values of groups III (EE clinically possible [clin. poss.]) and IV (prob./def.) were markedly lower in the upper 3 regions of measurements (Table 3).