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AJNR - American Journal of Neuroradiology

Published ahead of print on September 3, 2008
doi: 10.3174/ajnr.A1202

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Whole-Brain Voxel-Based Morphometry in Kallmann Syndrome Associated with Mirror Movements

M. Koenigkam-Santos^a, A.C. Santos^a, T. Borduqui^c, B.R. Versiani^b, J.E.C. Hallak^c, J.A.S. Crippa^c and M. Castro^b

^a Division of Radiology, School of Medicine of Ribeirao Preto-University of Sao Paulo, Ribeirao Preto, SP, Brazil
^b Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine of Ribeirao Preto-University of Sao Paulo, Ribeirao Preto, SP, Brazil
^c Department of Neurology, Psychiatry, and Medical Psychology, School of Medicine of Ribeirao Preto-University of Sao Paulo, Ribeirao Preto, SP, Brazil

View larger version (100K): [in this window] [in a new window]   Fig 1. Regional cortical gray matter volume increase (orange/red) and reduction (blue) in patients with KS and MM relative to control subjects. Significant voxels (height threshold of P < .001, uncorrected for multiple comparisons and an extent threshold of 25 voxels) are superimposed on selected sections of spatially normalized MR images from a control subject. With the hypothesis a priori, areas of increased gray matter are seen around the left central sulcus, in the primary motor cortex, Brodmann area 4 (the cluster with 122 voxels), and the primary somatosensory cortex, area 3 (the cluster with 93 voxels).

View larger version (110K): [in this window] [in a new window]   Fig 2. Regional cortical gray matter volume increase (orange/red) and reduction (blue) in patients with KS without MM relative to control subjects. Significant voxels (height threshold of P < .001, uncorrected for multiple comparisons and an extent threshold of 25 voxels) are superimposed on selected sections of spatially normalized MR images from a control subject. With the hypothesis a priori, areas of increased gray matter are seen in the left frontal lobe, Brodmann area 6 (the cluster with 304 voxels), and in the right precentral gyrus, contralateral area 4 (the cluster with 27 voxels).