AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on November 11, 2008
doi: 10.3174/ajnr.A1363
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Temporal and Spatial Development of Axonal Maturation and Myelination of White Matter in the Developing Brain

W. Gaoa, W. Linb, Y. Chenc, G. Gerige, J.K. Smithc, V. Jewellsc and J.H. Gilmored

a Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC
b Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
c Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
d Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC
e Scientific Computing and Imaging Institute, Utah University, Salt Lake City, Utah


Figure 1
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  		Fig 1. Representative examples of axial diffusivity, radial diffusivity, and FA from 3 subjects; 1 subject for each age group is shown. All images are scaled to the same window and level settings to allow a direct comparison across subjects. Both the axial and radial diffusivities decrease, whereas the FA increases with age.


Figure 2
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  		Fig 2. The main values of the axial diffusivity, radial diffusivity, and FA from all 8 regions of interest are shown. A significant reduction (P < .0001) of both axial and radial diffusivities and elevation (P < .0001) of FA are observed from neonates to 1-year-olds. The changes from 1- to 2-year-olds are more subtle for both axial diffusivity and FA, whereas a significant reduction (P = .0014) in radial diffusivity is observed. The labels for the left and right y-axis represent the directional diffusivities and FA, respectively.


Figure 3
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  		Fig 3. Statistical comparison results overlaid on FA maps are shown. Note that the red/yellow/green regions of interest are shown for illustration. The body of the corpus callosum should be located on a different section, but it was shown on the same section for visualization.


Figure 4
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  		Fig 4. Comparisons of axial diffusivity (A), radial diffusivity (B), and FA (C) across age. The experimentally measured values of the 1- and 2-year-old groups are normalized to that of the neonates.


Figure 5
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  		Fig 5. Comparisons of the axial diffusivity (A), radial diffusivity (B), and FA (C) across regions of interest but at the same age are shown.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X