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AJNR - American Journal of Neuroradiology

Published ahead of print on November 11, 2008
doi: 10.3174/ajnr.A1355

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MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength

R.N.K. Nandigam^a, A. Viswanathan^a, P. Delgado^a, M.E. Skehan^a, E.E. Smith^a, J. Rosand^a, S.M. Greenberg^a and B.C. Dickerson^b,c

^a Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass
^b Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass
^c Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Mass

View larger version (108K): [in this window] [in a new window]   Fig 1. MR images from individual subjects illustrating increased contrast. The pairs of images illustrate comparisons of thick-section GRE (A) versus thin-section SWI (B, Table 3); thin-section GRE (C) versus thin-section SWI (D); thick-section GRE (E) versus thin-section GRE (F; all preceding images at 1.5T); and SWI at 1.5T (G) versus SWI at 3T (H). Image parameters are shown in Table 1. The black arrows in Fig 2A and B illustrate a CMB prospectively counted on both sequences, whereas lesions denoted by white arrows were initially identified only on the SWI image. The black arrows in the remaining images highlight lesions on the paired images for comparison.

View larger version (16K): [in this window] [in a new window]   Fig 2. Detection of CMB as a function of lesion contrast and diameter. Scatterplots show CI (A), diameter (B), and a 2D plot of both parameters (C) of CMB prospectively identified (filled circles) or not prospectively identified (empty circles) by a blinded rater on clinical GRE MR images. C, The CMB in the lower right corner (solid arrow) were identified on GRE alone despite its lower CI, most likely because of its relatively large diameter. Conversely, the low-diameter CMB in the upper left corner of the figure (dashed arrow) were missed on GRE despite their relatively high CI. All measurements of CI and diameter were performed on the GRE images.