AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on December 26, 2008
doi: 10.3174/ajnr.A1397
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Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease

R.S. Desikana, H.J. Cabralb, B. Fischld,g, C.R.G. Guttmannh, D. Blackere, B.T. Hymanf, M.S. Alberti and R.J. Killianya,c,e,h

a Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Mass
b Department of Biostatistics, Boston University School of Public Health, Boston, Mass
c Department of Environmental Health, Boston University School of Public Health, Boston, Mass
d Department of Radiology, Massachusetts General Hospital, Boston, Mass
e Athinoula A. Martinos Center for Biomedical Imaging, Psychiatry, Massachusetts General Hospital, Boston, Mass
f Department of Neurology, Massachusetts General Hospital, Boston, Mass
g Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Mass
h Department of Radiology, Brigham and Women's Hospital, Boston, Mass
i Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Md


Figure 1
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  		Fig 1. Illustration of the location of the inferior parietal and medial temporal regions of the brain on a 3D image on 1 hemisphere of the brain. Please see Fig 5 from Fischl et al, 200238 and Fig 1 from Desikan et al, 200637 for a detailed color depiction of all 16 temporoparietal regions of interest used in this study.


Figure 2
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  		Fig 2. Survival curves for prediction of time to progression from MCI to a diagnosis of AD (based on the adjusted univariate model [shown at the mean, and 1 SD above and below the mean]), as a function of variation in the MR imaging volume of the inferior parietal lobule (A) and the entorhinal cortex (B).





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