Advanced

AJNR - American Journal of Neuroradiology

Published ahead of print on April 22, 2009
doi: 10.3174/ajnr.A1476

This Article Free to Access Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Escolar, M.L. Articles by Styner, M. Search for Related Content PubMed PubMed Citation Articles by Escolar, M.L. Articles by Styner, M.

Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tracts of Neonates with Infantile Krabbe Disease

M.L. Escolar^a, M.D. Poe^b, J.K. Smith^c, J.H. Gilmore^d, J. Kurtzberg^f, W. Lin^d and M. Styner^d,e

^a Program for Neurodevelopmental Function in Rare Disorders at the Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC
^b FPG Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC
^c Departments of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
^d Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC
^e Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC
^f Pediatric Blood and Marrow Transplantation Program, Duke University Medical Center, Durham, NC

View larger version (58K): [in this window] [in a new window]   Fig 1. Visualization of DTI fiber tracts through the right hemispheric internal capsule with FA coloring of the fibers from a lateral viewpoint. Top row: 5 representative control subjects. Bottom row: 4 selected Krabbe subjects. Visually, all Krabbe subjects show lower FA values along most of the fiber bundle than any of the controls.

View larger version (8K): [in this window] [in a new window]   Fig 2. Raw FA mean values for patients with infantile Krabbe disease and controls. Each point represents a child's mean FA across the central portion of the corticospinal tract. The red triangles represent the 6 patients with Krabbe disease, whereas the blue diamonds show the typical controls. The red and blue lines represent the linear trend related to corrected age at the time of the MR imaging.

View larger version (11K): [in this window] [in a new window]   Fig 3. Normalized FA ratios for patients with infantile Krabbe disease and controls. The FA ratio is the observed FA divided by the expected FA. given the child's gestational age at birth, corrected age at scanning, birth weight, and sex. The red triangles represent the 6 patients with Krabbe disease, whereas the blue diamonds show the typical controls. The horizontal black lines represent the SDs based on the controls.