AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on March 11, 2009
doi: 10.3174/ajnr.A1484
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Alterations in Cortical Thickness and White Matter Integrity in Mild Cognitive Impairment Measured by Whole-Brain Cortical Thickness Mapping and Diffusion Tensor Imaging

L. Wanga,e, F.C. Goldsteinb, E. Veledarc, A.I. Leveyb, J.J. Lahb, C.C. Meltzera,b,d, C.A. Holdera and H. Maoa

a Department of Radiology, Emory University School of Medicine, Atlanta, Ga
b Department of Neurology and the Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, Ga
c Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Ga
d Department of Psychiatry and Behavior Sciences, Emory University School of Medicine, Atlanta, Ga
e Department of Radiology, The Second Hospital of Shenzhen, Shenzhen, Guangdong, China


Figure 1
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  		Fig 1. Examples of ROIs placed in the temporal (A) and prefrontal (B) areas and CC (C) of the FA map.


Figure 2
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  		Fig 2. Cortical thickness was measured in cortical structures shown in this 3D rendering view of the brain from outside (A) and inside (B). The cortical structures, where statistically significant changes were observed in the MCI groups, are highlighted in the different colors to distinguish each cortical region, which is numbered as 1, bankssts; 2, entorhinal; 3, frontal pole; 4, fusiform; 5, inferior temporal; 6, middle temporal; 7, paracentral; 8, parahippocampal; 9, pars orbitalis; 10, pars triangularis; 11, postcentral; 12, rostral middle frontal; 13, superior parietal; 14, superior temporal.


Figure 3
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  		Fig 3. FA (A) and ADC (B) values in different ROIs of the MCI and control groups.


Figure 4
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  		Fig 4. Decreases in cortical thickness were observed in the MCI group in several cortical structures (colored) of the left and right hemisphere. Bank, bankssts (ie, cortical areas around superior temporal sulcus); En, entorhinal; FP, frontal pole; FF, fusiform; IFT, inferior temporal; MT, middle temporal; ParaC, paracentral; PH, parahippocampal; PO, pars orbitalis; PT, pars triangularis; PostC, postcentral; RMF, rostral middle frontal; SP, superior parietal; ST, superior temporal areas.


Figure 5
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  		Fig 5. The levels of sensitivity and specificity to predicting MCI are shown in the plot of the ROC analysis. Combining the FA measurement of WM changes and the cortical thickness measurement of GM changes in the left hemisphere resulted in the increased AUC (blue line), ie, improved sensitivity and specificity to differentiate MCI from the control subjects compared with those of the FA measurement (red) or cortical thickness analysis (green) alone.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X