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AJNR - American Journal of Neuroradiology

Published ahead of print on March 6, 2009
doi: 10.3174/ajnr.A1517

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White Matter Damage in Carbon Monoxide Intoxication Assessed in Vivo Using Diffusion Tensor MR Imaging

W.-C. Lin^a,d, C.-H. Lu^b, Y.-C. Lee^f, H.-C. Wang^c, C.-C. Lui^a, Y.-F. Cheng^a, H.-W. Chang^g, Y.-T. Shih^a and C.-P. Lin^d,e

^a Departments of Diagnostic Radiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China
^b Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China
^c Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China
^d Department of Biomedical Imaging and Radiological Sciences, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, Republic of China
^e Lab for Brain Connectivity, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, Republic of China
^f Department of Diagnostic Radiology, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan, Republic of China
^g Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, Republic of China

View larger version (138K): [in this window] [in a new window]   Fig 1. Location of the WM regions of interest in a patient with CO intoxication. A, WM of temporal lobes. B, WM of orbitofrontal, occipital, anterior, and posterior limbs of the internal capsule. C, Genu and splenium of the corpus callosum. D, WM of the frontal and parietal lobes.

View larger version (56K): [in this window] [in a new window]   Fig 2. A 57-year-old man with delayed neuropsychiatric syndrome after CO intoxication (upper) and a healthy control (lower). A and B, Axial T2-weighted images (A) and FLAIR MR images (B) show symmetric necrosis of the bilateral globus pallidus and extensive hyperintensity of the subcortical WM. C, ADC map. D, The FA map of DTI reveals clearly reduced fiber integrity of the corresponding WM. The color bar represents the FA values.

View larger version (10K): [in this window] [in a new window]   Fig 3. Scatterplots show the FA value of average overall WM versus MMSE (A) and digit span backward results (B) in patients with CO intoxication.