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FIG 1. Two-dimensional plot of mean MTR values versus time (in months). MTR values are stratified according to the appearance of MS lesions on the baseline contrast-enhanced T1-weighted image. Hypointense nonenhancing, nodular-enhancing, and ring-enhancing lesions show a significant MTR increase on the 12-month image. The increase is higher for ring-enhancing lesions and occurs mainly during the first 3 months. MTR values in the NAWM and the isointense nonenhancing lesions do not show significant changes. Open circles indicate NAWM; triangles, isointense without enhancement; solid circles, nodular-type enhancement; squares, hypointense without enhancement; diamonds, ring-type enhancement.
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