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FIG 3. A–E, Electron microscopy of transvascular delivery of iron particles. Rat brain micrographs after BBB disruption-enhanced delivery of Feridex are shown in A (original magnification x19,000), B (original magnification x48,000), and C (original magnification x87,000). Electron-dense particles (arrows) are located around capillaries, adjacent to the basement membrane (BM) and pericapillary pericyte (P). L = capillary lumen, MA = myelinated axon, EC = capillary endothelial cell. Location of MION after BBB disruption is shown in D (original magnification x65,000) and E (original magnification x36,700). Electron-dense MION particles (D, arrows) were found near synapses (S) and mitochondria (Mt). MION particles were detected in pericapillary pericytes (P) and in what appear to be pericyte processes (E, arrow). EC = capillary endothelial cell, RBC = red blood cell, BM = basement membrane
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