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FIG 2. A and B, Coronal SE T2-weighted images of the brains of two rats with clinical EAE, imaged 24 hours after administration of USPIO (AMI-227) at 4.7 T. The section is at the level of the posterior fossa (arrowheads indicate the right cerebellar hemisphere; long arrows, the pons). Numerous lesions are seen as low signal intensities related to the magnetic susceptibility effects caused by iron particles within phagocytic cells (small arrows in A).
FIG 3. Coronal turbo SE T2-weighted (5000/20/1) MR image of the brain of a rat with EAE, imaged 24 hours after administration of AMI-227 at 1.5 T. Multiple areas of low signal are seen within the posterior fossa (arrows).
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