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FIG 4. Histologic sections at a site of low signal on MR images after administration of AMI-227.
A, Hematoxylin-eosin stain shows multiple perivascular inflammatory infiltrates (arrows).
B, Prussian blue stain for iron (Perls' technique) shows staining of perivascular cells (arrows).
>>FIG 5. Histologic section at the level of the posterior fossa (arrow indicates fourth ventricle) shows immunostaining with an ED1 antibody macrophage marker. Macrophage infiltrates correspond to magnetic susceptibility–related low signal intensities on T2-weighted images 24 hours after USPIO injection and to infiltrating cells on hematoxylin-eosin stain.
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