American Journal of Neuroradiology 20:1127-1131 (6 1999)
© 1999 American Society of Neuroradiology
ARTICLE
Craniocervical Junction Venous Anatomy on Enhanced MR Images: The Suboccipital Cavernous Sinus
Ronald D. Caruso,a,
Arthur E. Rosenbauma,
Ja Kwei Changa and
Stephen E. Joya
a From the Department of Radiology, S.U.N.Y. Health Science Center, 750 E Adams St, Syracuse, NY 13210.
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Abstract
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BACKGROUND AND PURPOSE: The suboccipital cavernous sinus, a
vertebral venous plexus surrounding the horizontal portion of
the vertebral artery at the skull base, provides an alternative
pathway of cranial venous drainage by virtue of its connections
to the cranial dural sinuses, the vertebral venous plexus, and
the jugular venous system. Knowledge of the anatomy of this
system facilitates interpretation of images and might reduce
the number of false-positive diagnoses of lesions, such as adenopathy
or schwannoma. We hypothesized that this circulation could be
visualized on contrast-enhanced, fat-suppressed T1-weighted
MR images.
METHODS: The craniocervical junctions of 14 patients were scanned using fat-suppressed, contrast-enhanced, T1-weighted MR sequences and evaluated for visibility of the following venous structures: suboccipital cavernous sinus, vertebral artery venous plexus, anterior and posterior condylar veins, vertebral venous plexus, internal jugular vein, and the marginal sinus. Both the right and left sides were assessed in at least two planes. The venous diameters were also measured.
RESULTS: All the evaluated venous structures were seen routinely in all three planes, with the exception of the posterior condylar vein, known to be variably present, which was seen only one third of the time in the sagittal plane and two thirds of the time in the other planes. The posterior condylar vein also showed the greatest variability in size and symmetry.
CONCLUSION: The suboccipital cavernous sinus and most of its associated venous circulation at the skull base are easily identified on contrast-enhanced, fat-suppressed T1-weighted MR images. The posterior condylar vein, known to be variably present, was not well seen in the sagittal plane and displayed the greatest variability in size and symmetry.
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Introduction
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The venous circulation at the craniocervical junction has been
described primarily in the neurosurgical, anatomic, and angiographic
literature, with most cross-sectional imaging reports limited
to descriptions of isolated emissary vessels or lesions, mainly
vascular malformations, that cause venous enlargement (
1–
21).
Arnautovic et al (
1) recently evaluated and reviewed the venous
circulation at the craniocervical junction. These authors diagrammed
the numerous interconnections of an entity they called the suboccipital
cavernous sinus, which they defined as the venous compartment
surrounding the horizontal segment of the vertebral artery at
the skull base (
Fig 1). Knowledge of this skull base venous
anatomy is important in the understanding of pathologic processes
and in differentiating normal structures from lesions. We hypothesized
that this venous circulation could be well seen on contrast-enhanced,
fat-suppressed T1-weighted MR images.
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FIG 1. Posterior view of the right suboccipital cavernous sinus and its venous communications at the skull base. The vertebral artery has been removed. The left suboccipital cavernous sinus would form a mirror image, with direct connection of the marginal sinus and vertebral venous plexus across the midline. M indicates medial; L, lateral; C1, atlas; C2, axis; O, occipital region; acv, anterior condylar vein; av, anastomotic vein; jb, jugular bulb; jv, jugular vein; lcv, lateral condylar vein; lr, lateral ring; ms, marginal sinus; pcv, posterior condylar vein; scs, suboccipital cavernous sinus; vavp, vertebral artery venous plexus; vvp, vertebral venous plexus. Adapted from (1) with permission
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Methods
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The venous circulation at the craniocervical junction in 14
patients was evaluated on all MR images (obtained at 1.5 T)
over a 16-month period that met the following criteria: 1) craniocervical
junction coverage to lower C2 in at least two planes, 2) T1-weighted
spin-echo technique with fat suppression, 3) contrast enhancement
(0.1 mM/kg of gadolinium chelate for 12 patients and half that
dose for two patients), 4) section thickness of 3 to 4 mm, and
5) no evidence of venous occlusive disease or arteriovenous
shunting. Imaging was performed for a variety of clinical problems,
the most common being neurosensory hearing loss. Four images
were evaluated retrospectively and 10 prospectively.
Images were evaluated independently by four faculty neuroradiologists for conspicuity of the suboccipital cavernous sinus and the following structures that communicated with it: 1) vertebral artery venous plexus (except in the sagittal plane in two patients), 2) anterior condylar vein, 3) posterior condylar vein, 4) internal vertebral venous plexus, and 5) marginal sinus. The internal jugular vein, including the bulb, was also evaluated. Of the 14 patients, seven were women and seven men; average ages were 48 and 36 years, respectively, with most patients in their fourth and fifth decades. One patient had imaging studies in all three planes; the remaining 13 in two planes. Both sides were evaluated in each plane for a total of 28 coronal, 18 axial, and 12 sagittal assessments in the 14 patients. Disagreements among the four physicians were settled by a majority vote; in all instances, a consensus was reached.
In addition to the above determinations, the venous structures were measured on a computer monitor using electronic calipers; their relative degree of bilateral symmetry was assessed.
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Results
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Tables 1 and
2 summarize our results. The venous structures
studied could be detected reliably in all three planes (
Figs 2–5
) with the exception of the posterior condylar vein
in the sagittal plane, which was detectable only a third of
the time; conversely, it was seen two thirds of the time in
the other planes. Generally, the axial and coronal planes proved
to depict the venous anatomy to greatest advantage.
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Table 1: Normal suboccipital venous structures seen in 14 patients using contrast-enhanced T1-weighted fat-suppressed sequences*
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Table 2: Summary of measured diameters of normal suboccipital venous structures in 14 patients using contrast-enhanced T1-weighted fat-suppressed MR sequences*
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FIG 2. 45-year-old man referred for follow-up of a presumed schwannoma posterior to the left occipital condyle, shown to be the left posterior condylar vein.
A and B, Contrast-enhanced fat-suppressed T1-weighted (640/14/3) coronal images (A posterior to B) show the suboccipital cavernous sinus (asterisk), marginal sinus (arrowhead), posterior condylar vein (short arrows), and vertebral venous plexus (long arrows). The right posterior condylar vein is diminutive.
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FIG 3. 43-year-old man. Contrast-enhanced fat-suppressed T1-weighted (950/12/2) coronal image in a plane anterior to figure 2 shows the anterior condylar vein (arrowhead) and the jugular vein (asterisk) at the jugular tubercle, the vertebral venous plexus (curved arrow), and the vertebral artery venous plexus (straight arrow)
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FIG 4. 68-year-old woman.
A and B, Contrast-enhanced fat-suppressed T1-weighted (630/20/2) axial images (superior to inferior) show the anterior condylar vein (large straight arrow), suboccipital cavernous sinus (curved arrow), vertebral venous plexus (arrowhead), vertebral artery venous plexus (small straight arrows), and anastomotic vein (wavy arrow).
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FIG 5. 34-year-old woman.
A–D, Contrast-enhanced fat-suppressed T1-weighted (820/12/2) axial image (in a plane between fig 4A and B) (A) and T1-weighted (700/12/2) sagittal images (medial to lateral) (B–D) show the posterior condylar vein (straight arrow, A and D) at the posterior aspect of the occipital condyle, marginal sinus (arrowhead, A), suboccipital cavernous sinus (wavy arrow, C and D), vertebral venous plexus (curved arrow, B and C), suboccipital venous plexus (wavy arrows, B), anterior condylar vein (open arrow, C), and anastomotic vein (asterisk, D).
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The vertebral artery venous plexus, suboccipital cavernous sinus, and anterior condylar vein showed the least variation from patient to patient; the posterior condylar vein and jugular vein and bulb showed the most. The posterior condylar vein and, to a lesser extent, the jugular vein and bulb displayed the greatest asymmetry. The remaining vessels were remarkably symmetrical. In some patients, the vertebral artery venous plexus and suboccipital cavernous sinuses were mildly asymmetrical, which was related to the size of their corresponding vertebral arteries and their foramina. Usually, the variation in size of the venous structure was less than that of the artery within it.
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Discussion
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Arnautovic et al (
1) recently reviewed and analyzed the venous
anatomy at the craniocervical junction. These investigators
emphasized the importance of the suboccipital cavernous sinus,
a term they proposed to describe the venous compartment surrounding
the horizontal portion of the vertebral artery at the skull
base (
Fig 1). They described its many communications, including
the following: 1) anterior condylar vein, connecting to the
jugular bulb via the anterior condylar (hypoglossal) canal in
the region of the jugular tubercle; 2) posterior condylar vein,
connecting to the jugular bulb via the posterior condylar canal
at the posterior aspect of the occipital condyle; 3) lateral
condylar vein, which connects to the internal jugular vein at
the lateral aspect of the occipital condyle; 4) vertebral artery
venous plexus, the venous plexus surrounding the vertical segment
of the vertebral artery at the level of the axis, which connects
to the vertebral venous plexus and continues inferiorly as vertebral
veins; 5) marginal sinus, the sinus in the dura leaves at the
margin of the atlantooccipital ligament, which connects to the
occipital and basilar venous sinuses superiorly and to the vertebral
venous plexus inferiorly; 6) vertebral venous plexus, consisting
of internal (epidural veins within the bony spinal canal) and
external (other paravertebral and intravertebral veins) components,
which interconnect at each level and also communicate with the
vertebral artery venous plexus, the marginal sinus, and with
the opposite suboccipital cavernous sinus; and 7) anastomotic
vein, which connects to the suboccipital venous plexus, a variable
plexus posterior to the suboccipital cavernous sinus, located
between the deep and intermediate muscle layers and having interconnections
of its own.
Previous investigators have shown that the vertebral venous plexus performs in concert with the jugular venous system in the drainage of the cranial cavity in healthy patients, providing an important additional pathway (2–5). It has been noted on angiograms in both monkeys and humans to provide the majority of cranial drainage in the upright position (2–5); this probably relates to a relative increase in intrathoracic pressure (3). The plexus is important as a reservoir and as an auxiliary drainage pathway in certain situations, such as during the Valsalva maneuver and when the jugular circulation is compromised (2–5). Venous enlargement may occur in a variety of lesions, including vascular malformations and venous obstructive lesions (4–11). An instance of greatly enlarged craniocervical epidural veins after craniectomy has recently been reported (11). Epidural venous congestion and enlargement may accompany intracranial hypotension (12, 13).
This study represents a work in progress, with several attendant limitations. Our study population was relatively small. We did not study the lateral condylar vein, owing to its very small size, or the anastomotic vein and suboccipital venous plexus, because we did not include the posterior soft tissues in the coronal plane; the intradural venous circulation was not studied. The posterior condylar vein, previously reported by Ginsberg (14) and Weissman (15) to be commonly asymmetrical or absent, was the most difficult vein to evaluate, owing to its frequent variation in size and symmetry and its potential, when small, for partial volume averaging with the suboccipital cavernous sinus. It was seen in only one third of the sagittal evaluations and two thirds of the coronal and axial evaluations. The remaining vessels were easy to identify in all planes because of their specific relationships to bony landmarks.
Our observations only relate to the resting patient in the supine position. A small portion of the "venous" enhancement of the suboccipital cavernous sinus and vertebral artery venous plexus may represent flow-related enhancement of the vertebral artery or enhancement of its vasa vasorum. Dural enhancement may contribute a small component. Pressure from the surface coil on the neck may affect venous filling. Our measurements may have been affected by volume averaging.
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Conclusion
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The venous circulation of the craniocervical junction, anchored
by the suboccipital cavernous sinus, is well seen on contrast-enhanced,
fat-suppressed T1-weighted MR images. The axial and coronal
planes provide the best view. All the venous structures studied
were easily identifiable in all patients, except for the posterior
condylar vein, which was highly variable in terms of size, symmetry,
and presence. The jugular vein was frequently asymmetrical.
The remaining vessels were remarkably symmetrical. The least
variation from patient to patient was displayed by the vertebral
artery venous plexus, suboccipital cavernous sinus, and anterior
condylar vein; the most variation by the posterior condylar
vein and jugular vein.
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Acknowledgments
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We are grateful to John P. Griffin for his technical assistance
and helpful suggestions.
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Footnotes
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101 Presented at the annual meeting of the American Society of Head
and Neck Radiology, Phoenix, April 1998.
102 Address reprint requests to Ronald D. Caruso, MD.
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Received July 1, 1998;
accepted after revision February 9, 1999.
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Abstract
Introduction