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FIG 5. Imaging studies and histologic features found in marmoset HWM-1.
A, Preterminal PD- (3200/22/2) and T2-weighted (3200/110/2) MR brain images correspond to the LFB-stained whole-brain mount in the bottom row. On these slices focal lesions were present on the left side of the brain on the histopathologic and MR slices, whereas more confluent lesions were present on the right side of the brain (arrowheads). Histopathology for this animal is presented in figure 5B. The clinical and MR scores for this animal are presented in figure 1, panel A. (Scale bar equals 5 mm)
B, A histologic composite of LFB-stained lesions distributed throughout the CNS that is not confined to the LFB-stained whole-brain mount (fig 5A), is shown to demonstrate the disparity between lesion types that coexist in this model. The left panel reveals multiple perivascular inflammatory infiltrates with a well-delineated lack of LFB limited to the area of inflammation in the subcortical and deep WM. In these lesions, the inflammatory infiltrate is essentially within the Virchow-Robin space; thus, there is little, if any, true loss of myelin. The middle panel shows a more diffuse inflammatory infiltrate, again, around concentrically located vessels. In this panel the inflammatory infiltrate is minimally invasive to the parenchyma of the brain, with subsequent demyelination of the abutting axons. The right panel shows yet a more extensive inflammatory infiltrate surrounding centrally located vessels. The infiltrate extends well into the parenchyma with definite loss of myelin, giving the impression of patchy confluent lesions.
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