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FIG 1. A, Axial T2-weighted (3000/90/1) image in a patient with MS. Right periventricular lesion is poorly defined, with a halo of signal abnormality (arrow). In contrast, left periventricular lesion appears well circumscribed (arrowhead).
B, Contour plot applied to magnetization transfer map. Regions in green delineate areas with MTR less than 0.39; those in blue delineate areas with MTR less than 0.35, and those in black depict areas with MTR less than 0.32. This contour map reveals that both periventricular lesions are actually poorly defined, with gradations of surrounding MTR abnormality. The center of the left periventricular lesion appears as a small focus surrounded by a black contour line (arrow). This is surrounded by a blue contour (arrowhead), which in turn is encompassed by a green contour (double arrowheads). In fact, the green contour line surrounds all of the periventricular white matter, confirming a diffuse abnormality of the magnetization transfer parameters of the white matter.
C, Magnified view of contour plot applied to an MS plaque reveals fingerlike projections of abnormally low MTR values (arrowheads) extending into the white matter surrounding the lesion.
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