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FIG 1. The second step of the choice and delineation of gray matter lesions. Example with the choice and delineation of a deep gray matter lesion.
A, The axial proton density–weighted image of one of the relapsing-remitting MS patients showing a right temporal lesion involving the white matter and both deep and cortical gray matter.
B, The same lesion as selected by the software, in green color, after going through the step 1 (removal of the normal parts, CSF, and sulci).
C, Manual removal of the white matter and cortical gray matter constituting the lesion.
D, The isolated deep gray matter part of the temporal lesion.
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