|
FIG 4. Percent of participants with severe lesions in the insular subcortex white matter versus age. Cocaine-dependent participants had a significantly increased incidence of severe insular subcortex white matter lesions compared with normal control participants. The age dependence of the lesion incidence was significantly different in the two groups (eg, the shapes of the two lines differ). The lines are derived from logistic regression analysis of 62 cocaine addicts and 116 normal control participants. The raw data from each group were divided into age quartiles and are displayed at the median age of the quartile. The sample sizes of the age quartiles (in order of ascending age) were 10, 22, 14, and 16 for the cocaine group and 28, 29, 28, and 31 for the normal group. Severe lesions graded as grade 3 based on a 0 to 3 severity scale
|