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FIG 6. Percent of participants with severe lesions in the insular subcortex or cerebral white matter versus age. When the combined incidence of white matter lesions (cerebral or insular subcortex white matter) is used in the analysis, cocaine-dependent participants have a markedly significantly increased incidence of severe white matter lesions compared with normal control participants. The lines are derived from logistic regression analysis of 62 cocaine addicts and 116 normal control participants. The raw data from each group were divided into age quartiles and are displayed at the median age of the quartile. The sample sizes of the age quartiles (in order of ascending age) were 10, 22, 14, and 16 for the cocaine group and 28, 29, 28, and 31 for the normal group. Severe lesions graded as grade 3 based on a 0 to 3 severity scale
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