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FIG 1. Correlation coefficient maps of a representative subject show the activation patterns elicited by the four different paradigms.
A and B, In paradigms 1 (A) and 2 (B), unilateral finger tapping is compared with rest (right hand versus rest and left hand versus rest, respectively). Maximal activation is located contralateral to the side of motion in the left (paradigm 1) and right (paradigm 2) hemisphere, respectively. However, ipsilateral activation is also in the PMA (small arrowheads) and SMA (large arrowhead) (the SMA is only marginally met in the selected slice).
C, In paradigm 3 (both hands versus rest), activity is distributed nearly symmetrically between the two hemispheres. Primary as well as nonprimary motor areas are activated, making the precise identification of the central sulcus difficult.
D, In paradigm 4, right-handed motion is compared with left-handed motion (red indicates positive correlation of the voxels' signal time course with the task-derived reference function; blue, negative correlation). Functional activity is focused on the primary sensorimotor cortex around the central sulcus near the motor knob (arrowheads), reflecting the primary motor hand area (20).
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