|
FIG 2. Theophylline effect on the BOLD fMRI response to forepaw electrical stimulation. Results are the average for five test and four control animals. Five measurements were obtained in each animal: one before and four after the systemic injection of either 0.1 mmol/kg theophylline (n = 5) or an equivalent volume of normal saline (n = 4). The timing of each acquisition is relative to the systemic injection. The data for each animal were normalized to the preinjection value. * indicates a statistically significant difference compared with the baseline (P < .05).
A, The activated voxel count significantly increased 45 and 60 minutes after the administration of theophylline. It did not significantly change in the control group. The arrow indicates when theophylline or saline was administered, just after the first fMRI measurement.
B, The BOLD response amplitude significantly increased 45 and 60 minutes after the administration of theophylline, compared with baseline. It did not significantly change in the control group. The marker indicates when IP theophylline or saline was administered, just after the first fMRI measurement.
|