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FIG 2. Distribution of VSMCs on the surface of embolic devices. Images are argon-laser fluorescence confocal micrographs of embolic devices obtained after monopulse exposure assays (original magnification x40). Wide solid straight arrows indicate loops of the nitinol coil; curved arrows, collagen fibers; thin solid straight arrows, live cells; open arrows, dead cells.
A, CFBs exposed to an initial VSMC concentration of 2.6 x 104 cells per milliliter. VSMCs are spread over the convex surfaces of individual fibers and within the troughs between fibers.
B, Nitinol coils with a helical pitch of 50 µm exposed to an initial VSMC concentration of 2.6 x 105 cells per milliliter. VSMCs are preferentially distributed in the troughs between coil loops.
C, CINCs with a helical pitch of 250 µm exposed to an initial VSMC concentration of 2.6 x 105 cells per milliliter. VSMCs are focally concentrated on the surfaces of collagen fibers between consecutive coil loops.
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