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FIG 2. MR images in patient 1, who had disease with intermediate clinical severity.
A, Axial T2W image (3000/120), patient aged 18 months. The cerebral white matter contains little myelin. The putamen is mildly reduced in size (arrowhead). The thalamus, caudate nucleus, and globus pallidus (arrow) have a normal size.
B, Sagittal T1W image (570/14), patient aged 18 months. The cerebellar vermis is slightly atrophic.
C, Axial T2W image (3000/20, 60, 120), patient aged 6 years. At 6 years, the hypomyelination of the cerebral white matter is unchanged. The putamen is no longer visible. The head of the caudate nucleus is mildly reduced in size. The thalamus and globus pallidus (arrow) are normal.
D, Sagittal T1W image (570/14), patient aged 6 years. The cerebellar atrophy has increased.
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