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FIG 4. Procedure used to extract white matter and normal appearing white matter from T1 maps of study participants and patients.
A, T1 value of 1000.0 is used to threshold the T1 map.
B, White matter masks obtained by contouring the threshold T1 map.
C, The T1 distribution (solid line) obtained by applying the mask in B to the map in A. This distribution is fit to a Gaussian function (dot-dashed line) and converted into a probability distribution of T1 values.
D, White matter volume obtained by extracting pixels with T1 values within 90% probability (vertical lines in C).
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