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FIG 1. Patient 14 with Leigh syndrome.
A and B, Axial FLAIR images show bilateral and symmetrical hyperintensity of corpora striata. The VOIs used for spectroscopy are also shown.
C, Spectrum from the VOI containing the right affected putamen demonstrates resonances at 1.33 and 0.9 ppm coming respectively from lactate (Lac) and lipids or branched amino-acids (Lip/aa).
D, Abnormally high brain lactate (Lac) is also revealed in the spectrum from the VOI located in paraventricular white matter that appeared normal on the MR image.
Cho indicates choline; Cr, creatine.
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