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FIG 3. Histopathologic examination of the biopsies of the left cingulate gyrus revealed the morphology of a hemorrhagic-necrotizing inflammation (A, [H&E staining]) with multiple cells containing Cowdry type A intranuclear inclusions (insert). Immunohistochemical detection of HSV antigen is depicted in B. By using an antibody directed against the glial fibrillary acid protein, a prominent gliosis with multiple reactive astrocytes (C and D) intermixed with macrophages (B and C) could be detected. Astrocytes and macrophages are marked by arrows and arrowheads, respectively.
