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FIG 2. In vitro and in vivo clearance of transforming growth factor-ß1.
A, Blocks of alginate containing transforming growth factor-ß1 were kept in vitro and removed after 10 min to 7 days. The remaining activity was measured by scintillation counting, and the results are expressed as percentages of control activity.
B, Blocks of alginate containing transforming growth factor-ß1 were inserted in experimental aneurysms and removed after 10 min to 7 days. The remaining activity was measured by scintillation counting, and the results are expressed as percentages of control activity of blocks kept in vitro for identical time periods. In vitro and in vivo, the clearance of transforming growth factor-ß1 occurred in two phases: an initial rapid clearance (slope a) and a second slower phase (slope b).
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