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FIG 3. Postmortem correlation with MR imaging, cadaveric sections, and histology.
A, Axial T1-weighted MR imaging (TR/TE, 600/20; FOV, 10; matrix, 256 x 196; section thickness, 3 mm skip 1 mm) showing low-signal-intensity lesions of the right orbit in the intraconal space (black arrowhead). The normal retro-orbital fat is replaced by abnormal diseased tissue and the optic nerve is encased (white arrowhead). The extraocular muscles do not show any apparent alteration.
B, Cadaveric section showing the infiltrative disease (black arrowhead) at locations corresponding to the locations found with MR imaging. F+, retro-orbital fat; ON, optic nerve.
C, Macropathology demonstrating abnormal replacement of the retro-orbital fat by a dense fibrous material and conglomerates of lipid-laden macrophages (black arrow), which encase the optic nerve (black arrowhead). Hematoxylin and eosin preparation.
D, Histology with high magnification (magnification x200) showing involvement of the muscular interstitial space by attenuated fibrous material (black arrowhead).
E, Histology with high magnification (magnification x100) demonstrating the characteristic lipid-laden macrophages of ECD (open arrow).
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