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FIG 5. A, Postmortem coronal T2-weighted image of the right frontal lobe 8 months after the onset of symptoms in case 1, showing hyperintensities around the anterior horn of the lateral ventricle and adjacent deep cerebral white matter. B, Myelin-stained section corresponding to panel A, showing pallor of the cerebral white matter, which is more widespread than the extent of hyperintensities on the MR image. C, Histologic specimen of the area of moderately increased signal intensity (A and B, squares), revealing mild loss of myelin and axons with a few hypertrophic astrocytes (arrows). D, Area of normal signal intensity (A and B, circles), showing no apparent degenerative changes.
