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FIG 2. A, Statistical parametric maps show comparison of patients with early-onset AD with age-matched healthy volunteers (the younger control subjects). Highlighted areas are regions of significant gray matter loss in the patients with early-onset AD compared with age-matched control subjects at a threshold of P < .001, uncorrected. Bilateral medial temporal lobes, inferior parietal lobules, precuneus, and perisylvian cortices and the right inferior frontal gyrus and bilateral cingulate cortex are highlighted. L indicates left; R, right.
B, Statistical parametric maps show comparison of patients with late-onset AD and age-matched healthy volunteers (the older control subjects). Highlighted areas are regions of significant gray matter loss in patients with late-onset AD compared with age-matched control subjects at a threshold of P < .001, uncorrected. Bilateral medial temporal cortices are highlighted. L indicates left; R, right.
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