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FIG 2. Patient 2, who had MLD.
A and B, In vivo transverse T2-weighted image (A) and postmortem coronal 3D FLAIR image (B) show a hyperintense centrum semiovale with radially oriented stripes of hypointense signal intensity (arrows).
C, Photomicrograph (Luxol fast blue, original magnification x1) demonstrates a profound absence of myelin throughout the centrum semiovale with some sparing of the areas of subcortical U fibers.
D and E, Magnified views of hematoxylin and eosin (D, original magnification x37.5) and Luxol fast blue (E, original magnification x75) stains of the small box in C show that the hypointense linear bands correspond with numerous eosinophilic granule containing glial cells and macrophages (arrowheads) around venules (v) and myelin (blue stripes in E).
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