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FIG 3. Patient 3, who had GLD.
A and B, In vivo transverse T2-weighted image (A) and postmortem coronal 3D FLAIR image (B) show an atrophic brain with hyperintense white matter and linear areas of hypointense signal intensity, extending from the cerebral cortex to the ventricular wall (arrow).
C and D, Photomicrograph of hematoxylin and eosin stain (C, original magnification, x1.5) and magnified view of CD68 stain (D, original magnification x37.5) of the small box in C show perivascular clustering of multinucleated globoid cells (arrowheads, v = venule).
E, MBP stain (original magnification x75) shows almost complete absence of myelin sheaths (arrow).
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