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FIG 1. Example of a tissue sample and the matching area on postmortem MR images. WM lesions (WM), as well as type I lesions (I, mixed GM-WM), can be seen with relative ease on the different MR images. Intracortical lesions (IC) are difficult to detect and define, even in retrospect.
A, Photomicrograph (MBP immunohistochemical stain) reveals lesions (arrowheads) in the WM and cortical GM.
B, Short-echo T2-weighted SE image. Insert, a higher magnification of the intracortical lesion.
C, Long-echo T2-weighted SE image.
D, 3D FLAIR image.
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