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FIG 4. Electron micrographs of the affected median nerve after intravenous injection of horseradish peroxidase.
A, After 1 hour of perfusion, the dark reaction product of horseradish peroxidase leaks out of capillary under compression (asterisk).
B, Horseradish peroxidase leaked into the endoneurial space from capillary lumen owing to expansion of the tight junction (large arrow) and increased transcellular transport by pinocytotic vesicles (small arrow). The dark reaction products of horseradish peroxidase pass through from capillary lumen to endoneurial space. Occurrence of intraneural edema was shown (asterisk). The lumen has been cleared of horseradish peroxidase by perfusion fixation (A, x3,000; B, x25,000). En, endoneurial space; Et, endothelium; L, capillary lumen.
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