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FIG 1. Cytotoxicity of mannitol on endothelial and meningioma cells.
A, HUVECs stained with LIVE/DEAD kit. After treatment with 1200 mOsm for 15 minutes, almost all endothelial cells shrank and lost their typical cobblestone morphology. Many of them detached from the culture plate. Orange nuclei depicting dead cells can be seen on the remaining cells.
B, Meningioma cells stained with LIVE/DEAD kit. Similar cytotoxic effect is seen in the meningioma culture after incubation with 600 mOsm for 1 hour.
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