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FIG 1. A–M, MR images (T2-weighted, 2500/96; T1-weighted, 600/14), sonograms (US), and photomicrographs of paraffin sections (hematoxylin-eosin stain; original magnification, X2) of C6 glioma in rat brain. Each row shows the different modalities in one animal. Images in the first row (A–D) were obtained without contrast media, the second row of images (E–H) was gadolinium-enhanced, and images in the third row (J–M) were SPIO-enhanced.
A–D, On the nonenhanced images, the C6 glioma is predominantly hyperintense on the T2-weighted image (A) and isointense on the T1-weighted image (B). On the sonogram (C), the tumor appears iso- to slightly hyperechoic to brain tissue. With hematoxylin-eosin staining (D), the corresponding area is clearly identifiable.
E–H, After injection of gadopentetate dimeglumine, the tumor is hyperintense on the T1-weighted image (F) and reveals similar characteristics on T2-weighted image (E), sonogram (G), and hematoxylin-eosin staining (H) to those of the tumor on nonenhanced images.
J–M, Twenty-four hours after injection of SPIO particles, the tumor is inhomogeneously hypo- to hyperintense on T2-weighted (J) and T1-weighted (K) images. On the sonogram (L), the tumor appears inhomogeneously hyperechoic to brain tissue with hyperechogic margins.
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