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FIG 3. Glioblastoma multiforme. Gemistocytes were the most common cell type within the neoplasm (A; hematoxylin and eosin, original magnification x400). Immunostains for GFAP (B), neurofilament (C), and S-100 protein (D), are all at original magnification x400. Areas of vascular endothelial cell proliferation and necrosis (E and F, respectively; original magnification x100) characterize this lesion as a grade IV GBM.
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