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FIG 1. Manual and automated choice of the best AIF.
A, Manual choice, based on visual estimation of the overall shape of the curve, high signal intensity, early peak time, and small width.
B, Automatically computed AIF is identified as the one with the optimal combination of Gaussian-fit parameters (maximum A0 combined with A1 and A2 in the predefined limits) and the one satisfying the goodness-of-fit test.
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