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FIG 1. Regional brain atrophy measurement of the temporal lobes in a patient with secondary progressive multiple sclerosis. The top figure shows coronal 3D spoiled gradient-recalled acquisition in the steady state T1-weighted source image used for the segmentation of the temporal lobes. Panels A and C show the brain parenchymaonly and cerebrospinal fluidonly images of the right temporal lobe. Panels B and D show the same type of segmentation outputs in the left temporal lobe.