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FIG 2. A, top left, T2-weighted image of a 54-year-old patient with late-onset GM2G, superimposed with the 8 x 8 cm2 1H-MR spectroscopy VOI. Right, Two spectra from thalamus and occipital white matter (arrows 1 and 2).
B, bottom left, Corresponding section from a matched control. The arrows indicate analogous regions to A for metabolite spectral comparisons. All spectra are on common intensity and chemical shift (parts per million) scales.
Note the characteristic lower NAA signal intensity in thalamus and NAWM in the patient (A) compared with the control (B), as well as decreased Cr and Cho.
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