American Journal of Neuroradiology 26:2368-2370, October 2005
© 2005 American Society of Neuroradiology
Technical Note
INTERVENTIONAL
Stent-Assisted Coiling of Intracranial Aneurysms Aided by Virtual Parent Artery Reconstruction
Christof Karmonika,
Charles M. Strothera,
Xiaoyan Chenc,
Frank Deinzerc,
Richard Klucznikb and
Michel E. Mawada,b
a Department of Radiology, Baylor College of Medicine, Houston, TX
b Department of Radiology, The Methodist Hospital, Houston, TX
c Siemens Medical Systems, Erlangen, Germany
Address correspondence to Christof Karmonik, PhD, Department of Radiology, The Methodist Hospital, M 214, 6565 Fannin, Houston, TX 77030
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Abstract
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Summary: The availability of stents designed specifically for
use in the intracranial vasculature has increased the use of
stent-assisted coiling for treatment of wide-necked and complex
intracranial aneurysms. We present a technique for pretreatment
planning and visualization of a virtual stent within the parent
artery by using a virtual reconstruction of the parent artery
across the aneurysm neck. As illustrated by 2 clinical examples,
this method provides information not otherwise available regarding
the location of portions of the stent that are not visible on
fluoroscopy. During treatment, this information enhances the
ability to determine the location of coils in relation to the
stent boundaries and should thereby improve the ability to avoid
parent artery compromise.
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Introduction
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As a result of the complex relations between many aneurysms
and their parent artery and the inability to visualize a stent
fluoroscopically, it is often difficult to achieve a working
projection adequate to ensure that loops of coils are confined
behind a stent and are not compromising the parent artery lumen.
Consequently, we often find it necessary to use balloon-neck
protection as an adjunct to stent-assisted coiling. Because
this adds complexity to the procedure, we have developed and
retrospectively evaluated a pretreatment postprocessing algorithm
that provides a virtual image of the full extent of a stent
in the parent artery. Use of this technique seems likely to
then facilitate the ability to understand, during treatment,
the location of coils as they are placed and detached into an
aneurysm.
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Description of the Technique
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Angiographic data were obtained with a bi-plane C-arm system
(Axiom Artis, Siemens Medical System, Erlangen, Germany) by
using commercially available hardware and software. The algorithm
used for creating a virtual image of the full extent of a stent
in the parent artery was implemented as a plug-in for the 3D
image postprocessing software package, InSpace, on the Siemens
Leonardo workstation (version 2004B) as a research prototype.
The technical details of this algorithm are considered confidential
intellectual property at this time. A patent is pending. All
images were analyzed retrospectively after treatment had been
completed.
After a volume of interest containing the aneurysm and proximal and distal segments of the healthy parent artery had been chosen by manually clipping the 3D digital subtraction angiogram (3D-DSA) data, the centerline of the normal segments of the parent artery proximal and distal to the aneurysm was computed by using a skeletonization algorithm. From these centerline segments, the centerline of the parent artery across the aneurysm ostium was then interpolated. With this interpolation approach, an application of the presented technique to the most general case of a fusiform aneurysm within a curved vessel segment is possible. The quality of the reconstructed artery segment will depend on the particular details of the curvature and how well it can be interpolated from the healthy vessel segments adjacent to the aneurysm. Visual inspection of the results will always be necessary to verify a satisfying performance of the algorithm.
Next, a set of contiguous 2D cross-sections (cut planes) (
0.1-mm thickness) that contained the entire volume of the normal parent artery segments and the aneurysm and that was oriented perpendicular to the interpolated centerline was obtained. Then, for each cross-section containing a portion of the aneurysm, the corresponding radius of the virtual parent artery was linearly interpolated by using the radii measured at the normal proximal and distal segments of the parent artery. In this way, any natural tapering of the parent artery, if visible in the original 3D-DSA images, was taken into account by the algorithm.
The resulting reconstruction was then projected for analysis in 3 different views: (1) as a series of 2D cross-sections; (2) as a 3D cut surface reconstruction (clipped by a cut plane to allow inspection of the inside of the aneurysm); and (3) as a 3D surface-rendered volume.
Using this technique, we assessed the morphology of 2 aneurysms that were treated with stent-assisted coiling. One was a paraophthalmic aneurysm having a sidewall geometry (case 1) and the other was a carotid bifurcation aneurysm (case 2).
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Case 1: Wide-Neck Paraophthalmic Aneurysm
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The pretreatment anteroposterior (AP) and lateral 2D-DSA projection
images clearly show the course and size of the parent artery,
the aneurysm size, and the neck length (
Fig 1A, left and center).
The 3D-DSA surface volume reconstruction shows to better advantage
the expansion and irregularity of the portion of the ventral
wall of the internal carotid artery from which the aneurysm
arises (
Fig 1A, right). Neither of these show, however, that
the aneurysm ostium involves at least 180 degrees of the parent
artery circumference. This feature is clearly shown in the cut-plane
section and the cut-surface volume reconstruction (
Fig 1B, left and center). Both of these also demonstrate well the "pockets"
of the aneurysm that lie outside of the boundaries of the virtual
stent. The fit of the virtual stent can be verified in the 3D-DSA
surface volume reconstruction (
Fig 1B, right). Coil loops in
the "pocket" along the medial side of the aneurysm appear to
lie within the parent artery on the AP and lateral 2D-DSA projection
images (
Fig 1C). During treatment it was not possible to achieve
a working projection that separated clearly this component of
the aneurysm from the parent artery.
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FIG 1. (A) 2D-DSA pretreatment projection images (left: AP view, center: lateral view) and 3D-DSA surface volume reconstruction (right) for case 1. (B) Virtual artery reconstruction (left: selected cut-plane section; center: cut-surface volume reconstruction; right: 3D-DSA surface volume reconstruction). The blue circles mark the location of the virtual artery in each picture. The green arrows depict "pockets" or cul-de-sacs around the virtually reconstructed artery. (C) 2D-DSA posttreatment projection images (left: AP view; right: lateral view). Coil loops in the "pocket" along the medial side of the aneurysm appear to lie within the parent artery. Comparison with the cut-plane section and the cut-surface reconstruction in (B); however, show that they are actually located outside the stent.
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Case 2: Wide-Neck Carotid Bifurcation Aneurysm
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The AP and lateral pretreatment 2D-DSA projection images show
clearly the course of the parent artery, the aneurysm size and
the neck length. (
Fig 2A). The cut-plane section and cut-surface
volume reconstruction in a lateral projection and with a circle
inserted to show the location and size of the interpolated normal
parent artery demonstrate the extension of the aneurysm ostium
posterior to the boundary of the parent artery (
Fig 2B). Posttreatment
AP and lateral subtracted and unsubtracted images show coils
that appear to be within the parent artery (
Fig 2C). Comparing
these with the cut-plane section and cut-surface volume reconstruction
shows that these are, in fact, outside of the boundaries of
the stent and are not compromising the parent artery.
View larger version (81K):
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FIG 2. (A) 2D-DSA pretreatment projection images (left: AP view; right: lateral view) for case 2. (B) Virtual artery reconstruction (left: selected cut-plane section; right: cut-surface volume reconstruction). The blue circles mark the position of the virtual artery. The green arrows demonstrate the extension of the aneurysm ostium posterior to the boundary of the parent artery. (C) 2D posttreatment projection images (left: DSA AP view; center: DSA lateral view; right: native lateral view). Red arrows depict coils that appear to be within the parent artery.
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Discussion
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The availability of stents designed for use in the endovascular
treatment of aneurysms has enhanced the ability to treat wide-neck
intracranial aneurysms with endovascular techniques (
1,
2).
In our experience, because of the inability to directly visualize
these stents fluoroscopically, it is often difficult, or impossible,
to achieve a working projection adequate to be sure that coils
or coil loops are not herniating through a stent cell and causing
parent artery compromise. Because of this, we commonly employ
balloon-neck protection in conjunction with stent-assisted coiling.
As this increases the complexity, and possibly the risks of
the procedure, we have developed a technique that allows full
visualization of a virtual stent deployed across an aneurysm
ostium. If the technique were available as a pretreatment planning
aid, this would seem to offer enhanced ability to visualize
and to understand the complex relations between an aneurysm
and its parent artery.
Although commercially available 3D-DSA postprocessing techniques allow the depiction of the external anatomical features of intracranial aneurysms, they fail to depict clearly the topography of an aneurysm ostium to its parent artery. In an earlier publication we described and illustrated a technique for using 3D-DSA datasets to better characterize aneurysm morphology (3). In this report, we describe an extension of that technique that allows insertion and visualization of a virtual stent.
Using conventional image intensifier angiographic systems and a variety of postprocessing techniques, we have not been able to adequately visualize stents made of nitinol. We have, however, recently acquired a flat detector angiographic system, and early experience with this system indicates that it greatly enhances our ability to visualize these devices. Thus far, none of these techniques provide visualization equal to that obtained with the virtual stent technique.
The 2 examples given illustrate how the ability to visualize a virtual stent before treatment should improve the ability to monitor coil deposition during treatment because it provides the operator with a priori knowledge—both about the aneurysm ostium and about the parent artery and the location of stent boundaries that cannot be visualized directly during treatment.
Our technique does not model the stent deployment by highly sophisticated means such as finite elements, but rather assumes that a stent deployed so that it passes from a proximal segment of normal artery, across an aneurysm ostium, and into a distal segment of parent artery, will reconstruct the arterial boundaries to duplicate those of a normal artery. Looking at the 3D-DSA volume reconstructions for the 2 examples shown, one can see that the excellent fit of the reconstructed artery from which the aneurysm arises with the normal proximal and distal segments indicates that, in these 2 examples, this assumption is valid.
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Conclusion
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The technique described allows visualization of a virtual stent
in 3D-DSA volume reconstructions. This provides information
that will be valuable in pretreatment planning and should also
facilitate verification that coils are not herniating through
nonvisible portions of stents used for stent-assisted coiling.
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References
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- Alfke K, Straube T, Dorner L, Mehdorn HM, Jansen O. Treatment of intracranial broad-neck aneurysms with a new self-expanding stent and coil embolization. AJNR Am J Neuroradiol 2004;25:584–591[Abstract/Free Full Text]
- Wanke I, Doerfler A, Schoch B, Stolke D, Forsting M. Treatment of wide-necked intracranial aneurysms with a self-expanding stent system: Initial clinical experience. AJNR Am J Neuroradiol 2003;24:1192–1199[Abstract/Free Full Text]
- Karmonik C, Arat A, Benndorf G, et al. A Technique for improved quantitative characterization of intracranial aneurysms. AJNR Am J Neuroradiol 2004;25:1158–1161[Abstract/Free Full Text]
Received January 31, 2005;
accepted after revision May 12, 2005.
TOP
Abstract
Introduction