American Journal of Neuroradiology 27:354-355, February 2006
© 2006 American Society of Neuroradiology
TECHNICAL NOTE
SPINE
Recording CSF Pressure with a Transducer-Tipped Wire in an Animal Model of Chiari I
A. Turka,
B.J. Iskandarb,
V. Haughtona and
D. Consignya
a Department of Radiology, University of Wisconsin, Madison, Wis
b Department of Neurosurgery, University of Wisconsin, Madison, Wis
Address correspondence to Victor Haughton, MD, University of Wisconsin, 600 Highland Avenue, Department of Radiology, Madison, WI 53792-3252
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Abstract
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SUMMARY: In dogs, a wire with a pressure-sensitive transducer
was inserted percutaneously into the subarachnoid space and
manipulated under fluoroscopic monitoring in the posterior fossa
or upper cervical spinal canal. Pressure recordings from the
wire showed fluctuations in pressure corresponding to the cardiac
cycle. When a balloon was distended in the foramen magnum, maximum
and minimum pressures increased. Continuous monitoring of CSF
pressure remote from the site of cannulation was feasible with
a wire-based pressure transducer.
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Introduction
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Apressure-tipped wire has been used to record the pressure in
arteries and veins
1,
2 and within aneurysms.
3 Fluctuations in
pressure through the cardiac cycle are effectively demonstrated
with this wire. We designed a test of this transducer-tipped
wire to measure CSF pressures. We used an animal model in which
the foramen magnum was partially obstructed, to simulate a Chiari
I malformation.
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Methods
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Four adult mongrel dogs weighing 20–40 kg were used for
the study. The dogs were anesthetized with ketamine and intubated
in the dog laboratory. Oxygen levels and heart rate were monitored
by means of an oximeter and electrocardiography (EKG) leads
applied to the chest. The subarachnoid space was cannulated
through the L3/4 neural foramen with an 18-gauge spinal needle
as in a previous study.
4 By using Seldinger technique the spinal
needle was exchanged for a 6F sheath.
A microcatheter (Renegade Hi Flo; Target Therapeutics/Boston Scientific Industries, Fremont, Calif) with a Transcend EX guidewire (Target Therapeutics) was inserted through the sheath and manipulated to the level of foramen magnum under fluoroscopic monitoring. The guidewire was removed, and a 0.014-inch diameter wire equipped with a pressure sensor (Radi Medical Systems, Gothenburg, Sweden) was passed through the catheter. The wire was advanced under fluoroscopic monitoring until the pressure transducer mounted at the junction of the wire tip and core wire was positioned in the subarachnoid space at the level of cisterna magna or upper cervical spinal canal (Fig 1). A balloon catheter (Commodore 3.5 mm x 10 mm; Cordis Corporation, Miami Lakes, Fla) with the Transcend EX guidewire was then advanced through the sheath into the subarachnoid space. It was advanced, under fluoroscopic monitoring to a position in the foramen magnum (Fig 1). The pressure wire was connected to a recorder (Propaq Encore202, PROTOCOL Systems, Beaverton, Ore). The balloon was distended 3–5 times intermittently over a 10-minute time period by means of a hand injection of a dilute aqueous solution of water-soluble iodinated contrast medium. EKG was monitored for changes in cardiac rate. Before and after each balloon distension a paper trace of the pressure was obtained and maximal, minimal, and mean pressures were recorded from the values printed on the paper tracing.
The institution’s animal research supervisory committee approved the study.
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Results
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All 4 animals tolerated the procedures well. Heart rate varied
little except during the positioning of the wire in the foramen
magnum. In each animal, the wire was successfully manipulated
into the inferior posterior fossa or the upper cervical spinal
canal. Some repositioning of the wire was required to obtain
a continuous pressure trace in some animals, but, once the wire
was adequately positioned, the continuous pressure monitoring
was feasible.
Pressure varied through the cardiac cycle (Fig 2). Except when the balloon catheter was expanded or collapsed, pressures varied little from one cardiac cycle to another.
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Fig 2. CSF systolic, diastolic, mean, and pulse pressures in the CSF in dog 2 before and after inflation of the balloon catheter in the subarachnoid space.
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With distension of the balloon, no changes in cardiac rate were noted. When the balloon was distended, it appeared to compromise the foramen magnum partially in each case.
Within seconds after each distension of the balloon, increases in CSF pressures were recorded. After deflation of the balloon, pressures dropped to preinflation levels.
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Discussion
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The study shows that CSF pressure can be recorded in the subarachnoid
space with a transducer-tipped wire. Potentially, the wire can
be placed anywhere in the spinal subarachnoid space and if appropriate
techniques are employed, even in the cranial vault. The pressure
recording showed variation in pressure through the cardiac cycle
and little variation between cycles. In the experimental model
used, significant pressure increases were recorded as the balloon
in the foramen magnum was distended.
In other studies, the pressure measurements with the wire correlated exactly (r = 0.99) with the known values over a large range of pressures.1 The wire has been used intra-arterially.2–3 Applications in CSF pressure monitoring can be envisioned. With such a wire, fluctuations in CSF pressure below a block could be monitored during decompression of the spinal canal. The wire could theoretically be used to monitor CSF pressures as craniocervical decompression is performed in cases of Chiari I malformation or other foramen magnum abnormality. Specifically, one of the controversies of Chiari surgery is whether it is sufficient to remove the bone or whether duroplasty should be performed. We envision being able to insert a wire through the foramen magnum before the bony decompression and record pressures before and after the craniectomy and before and after duraplasty. Further, it might be useful to record the craniospinal pressure dissociation demonstrated with Chiari malformations by simultaneously recording pressures in the fourth ventricle and the upper cervical subarachnoid space.
The significance of this study is that CSF pressure can be measured (percutaneously) in the subarachnoid space with a small wire-mounted pressure transducer. With the transducer, elevated velocities have been documented secondary to partial obstruction of the foramen magnum in an animal model of a Chiari I malformation. Relatively safe invasive techniques such as this one would complement MR flow studies in helping us understand the CSF physiology at the foramen magnum. It is important to note that such studies would help elucidate the pathophysiology of obstructive foramen magnum lesions such as the Chiari I malformation.
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References
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- Gorge G, Erbel R, Niessing S, et al. Miniaturized pressure guide-wire: evaluation in vitro and in isolated hearts. Cathet Cardiovasc Diagn 1993;30:341–47[Medline]
- Nisanci Y, Sezer M, Umman B, et al. Relationship between pressure-derived collateral blood flow and diabetes mellitus in patients with stable angina pectoris: a study based on coronary pressure measurement. J Invasive Cardiol 2002;14:118–22[Medline]
- Sorteberg A, Sorteberg W, Turk AS, et al. Effect of Guglielmi detachable coil placement on intraaneurysmal pressure: experimental study in canines. AJNR Am J Neuroradiol 2001;22:1750–56[Abstract/Free Full Text]
- Purdy PD, White CL 3rd, Baer DL, et al. Percutaneous translumbar spinal cord compression injury in dogs from an angioplasty balloon: MR and histopathologic changes with balloon sizes and compression times. AJNR Am J Neuroradiol 2004;25:1435–42[Abstract/Free Full Text]
Received April 27, 2005;
accepted after revision July 20, 2005.
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Abstract
Introduction