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Fig 4. Axial T2*-weighted gradient-echo MR imaging (TR/TE, 450/4.2 ms, with resolution at 500 x 80 x 70 µm) at 7T performed 10 days after implantation of RT2 rat glioma into the brain of a mouse that received a tail vein infusion of 500,000 killed ferumoxides/poly-L-lysine–labeled Sca1+ endothelial precursor cells (A) or live 500,000 ferumoxides/poly-L-lysine–labeled Sca1+ endothelial precursor cells (B) 2 days before implantation of tumor. The hypointense ring (arrow) surrounding the tumor is clearly visible on the animal receiving magnetically labeled endothelial precursor cells and represents the incorporation of these cells into ongoing vasculogenesis and neovasculature of the growing tumor. Killed labeled cells served as a control and did not migrate to the tumor.17 MR imaging courtesy of Stasia A. Anderson, MD.
